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School of Life Sciences
Coursework assessment for Assessment Cycle [2] (semester [2],
2023/24)
LIFE 320 Virus Disease Mechanisms
Module organiser: Blake
Maximum word count: 1500 words
Please read all instructions (general and specific) carefully! Please also make sure to familiarise
yourself with the student guidance for written assessments (Canvas > OX-LIFE-Sciences-2022324 >
Assessment).
General instructions to students:
1. Word count
The word count is a maximum (not plus/minus 10%). There is no minimum word
count.
Please refer to the specific instructions below regarding what is and what isn’t
included in the maximum word count for this assignment.
Penalties will be applied for exceeding the word count as follows:
o Up to 1% (e.g. up to 2020 for a 2000 word maximum) no penalty
o Up to 10% (e.g. between 2021 and 2200 words) 5 % penalty
o Up to 20% (e.g. between 2201 and 2400 words) 10 % penalty
o Etc. (i.e. 5% penalty for every 10% above word count)
Enter your word count at the bottom of your submission
2. Submission
Your work should be submitted via the submission link in your module area in Canvas
Please make sure that you follow the guidance on written assessments which can be
found on the School Canvas Page.
Also refer to the School Canvas pages in relation to the penalties for Late Submission
and possible exemptions.
If you have any technical problems submitting to Canvas by the deadline, you must
email your work to the module organiser (copying in sls-assessment@liv.ac.uk ) by
the deadline, as evidence that you have submitted in time. You should also provide a
screenshot of the error you are experiencing. You should then continue to attempt
submitting via Canvas.
3. Academic Integrity
The University’s Academic Integrity policy and your annual Academic Integrity declaration
apply to this assessment. If necessary, the full range of penalties (Category A, B, C, D, and E)
will be available to examiners if they discover contraventions of the Academic Integrity
policy. You can consult the University’s Academic Integrity guide for students here:

点击以访问 appendix_L_cop_assess_annex1.pdf

Please remember you should follow the guidance given on making GAI Declarations by including the
appropriate statement in your work. :
Please note: Your answer should be written in your own words. Do not use any verbatim
(word for word) quotes. Your assignment may not contain verbatim (copy-and-paste)
material that you have submitted for another assessment, either on this or a different
module.
Expectations:
In this assessment, we expect students to write a well structured essay which correctly uses
the appropriate terminology and referencing. To provide context, you should give
background information based on the relevant module content. When you address the
question, you should use your knowledge and understanding of the module content, but
you should also use relevant literature to add a different perspective and/or more detail. At
the higher end of the marking scheme, markers will also be looking for an element of
criticality and synthesis. We will also expect a well founded conclusion.
Specific instructions:
No more than two figures should be used to support the information in the text.
Figures should be your own (i.e. drawn yourself and not taken directly, copy and pasted,
from another source).
If figures are used they must have a figure legend and be referred to in the text at the
appropriate place.
The word count does not include any text associated with figures, but figure legends should
be no more than 100 words.
References are not included in the word count.
Coursework Question(s):
A research virologist had recently carried out field work in a dense forest in Central Africa
where there were reports of a small number of people in an isolated community suffering
from a severe disease with a high mortality rate. The outbreak was thought to be due to an
unknown virus infection. The virologist brought samples back to their University to study in
high containment laboratories. A virus was isolated and the genome sequenced. This
indicated the virus had similarity to Marburg virus, and likely to belong to the same taxonomic
family. Interestingly, a unique open reading frame (termed ORF X) was identified that caught
the attention of researchers as the encoded protein had significant homology to interferon
regulatory factor 3 (IRF3). Shortly after returning home, the virologist developed similar but
much less severe symptoms, and recovered quickly. Samples were taken and a virus was
isolated.
Using the knowledge and information gained from the module, and from outside reading,
write an essay addressing the following questions:
Describe the virus family and genus to which this virus is thought to belong, including
details of the virion, genome and life cycle.
Discuss investigations that you would undertake to study the pathogenesis of both
viruses that were isolated, with specific details of the questions being addressed by the
studies you would employ.
Considering the return of the virologist to their home country, discuss potential public
health considerations.