There are two coursework activities that will be assessed in this module, both to be prepared and submitted individually.

In the first activity you will be assigned one of four different metabolic problem-solving exercises, involving an unknown enzyme and a simulated inhibitor of this enzyme. Your task will be to determine the identity of this enzyme and its kinetic parameters as well as the kinetic properties of the simulated inhibitor. To identify the enzyme, you must solve a metabolic clue. To determine the kinetic parameters of the enzyme and the properties of the inhibitor you will be given simulated experimental data, which you will have to process and interpret. You will submit your solution to the metabolic clue as a graphical abstract, while your calculations and results will be submitted using a pre-formatted excel spreadsheet. This will be accompanied by a 300-word conclusion/interpretation section. You are allowed to use graphs and figures. Text in graphs and figures or in their legends (within reason) will not count towards the word limit. More details will be revealed in live events and tutorials.

In the second activity you will be asked to create a differential diagnosis flow chart for diseases that cause jaundice. You only need to include diseases discussed in the GLD module in this module (extras are optional), but your flow chart should result in unambiguous diagnoses for each disease, even if you were to put it to real clinical use. You have the option to add a short 200-word figure legend to your flow charts. More details will be revealed in live events and tutorials.

Exceeding the word limit by up to 10% carries no penalty.

When do I need to submit my work? How will I get feedback?

Compile all components of your coursework into a single PDF document. This must be submitted via turnitin links, which will be posted in the “Module Assessment and Feedback Summary” tab in the MEDC0003 moodle page:

(link: https://moodle.ucl.ac.uk/course/view.php?id=6196#section-1)

The turnitin links will appear in the Assessment and Feedback session as soon as the submission period for that coursework opens. Each coursework will be supported by a series of tutorials and workshops as explained below:

Metabolism and Kinetics problem solving exercise (coursework 1):

Oct 25^th: You will receive your metabolic clue and simulated dataset by e-mail
Oct 27^th: Metabolic regulation tutorial. During the tutorial you will be given a worked example of a metabolic clue and shown how to write it up.
Nov 3^rd: Kinetics tutorial. During the tutorial you will be taught how to process a kinetics dataset, and you will be given an example to work through.
Following the kinetics tutorial, you will meet with your small group and jointly create a plan explaining how you plan to process your dataset.
Submit your plan as a group to the module lead (i.papaioannou@ucl.ac.uk) for formative feedback.
Your final report must be submitted as a pdf file before 6pm BST on Nov 25^th, 2022.

Differential diagnosis flow charts (coursework 2):

Oct 24^th: During the GLD introductory session you will be given a short workshop on the coursework, and you will be shown a model flow-chart.
Throughout the course you will be given a selection of clinical cases to solve, which will help you understand how the different diseases you study can be diagnosed. Use this data to create and test your flow chart.
Dec 12^th: The Turnitin 1^st draft submission link for this coursework will open. The draft submission link will close on the 10^{^th} of January 2023.
You will not suffer any penalties if you don’t submit a draft formative feedack, but historically failure to do so is strongly correlated with poor performance.
If you wish to submit a draft of your flow chart, you are advised to do so no later than Dec 23^rd. After this date, I will offer still offer feedback to as many drafts as I can on a first come, first serve basis and I cannot guarantee that everyone will get feedback.
You then have until 6pm on the 20^th of Jan 2023 to refine your flow chart and submit the final version.

Late submissions will be penalized according to UCL regulations:

Work submitted up to 48 hours late, must be deducted 10% of the mark
Work submitted 2-5 days late must be capped to 40% of the mark
Work submitted 5 or more days late will be given a mark of 1% and will be deemed complete.

How will my work be assessed?

· Your flow charts and essay will count for 30% of the final module mark.
Your write-up of your metabolic problem and kinetics experiment will count for 20% of the final module mark.
You will receive your grade together with the summative feedback one month after the due date of the coursework
The scoring Rubric and the SLMS Grade Descriptors for each coursework can be found below.

Scoring rubric for the Metabolism and Kinetics coursework

	Metabolic clue	Metabolic clue reasoning and research	Data processing	Data interpretation
17-20	Most or all of the clue components were correctly solved.	Evidence of exceptional insight into the function and biology of the enzyme	All data processing steps were executed correctly and most of the results were reported correctly	Evidence of advanced understanding of how this enzyme interacts with inhibitors
11-16	More than half of the clue components including the identity of the enzyme were correctly solved	Excellent explanation of the rationale and extensive evidence of independent research	More than half the data processing steps were corrected executed and reported	Correct interpretation of all the data, includes conclusions that require advanced knowledge.
6-10	More than half of the clue components were not solved correctly. Or the enzyme was not correctly identified	Rationale for the solution explained well and clear evidence of research beyond storylines and tutorials.	More than half the data processing steps were executed or reported incorrectly	Correct interpretation of most of the data that includes all obvious conclusions
0-5	Failed to correctly solve most of the clue	Unremarkable or incorrect reasoning and little or no evidence of independent research	Failed to correctly process most of the dataset	Little or incorrect interpretation of the data.
Score
Total (out of 80): Mark (%):

Scoring rubric for the Differential Diagnosis coursework

	Basic content	Accuracy	Advanced content	Reasoning
17-20	Covers most of the diseases and diagnostic criteria taught in the course.	The diagram/essay contains no errors, leading to incorrect or uncertain diagnoses.	Exceptional further research into differential diagnosis as applied to current clinical practice	Outstanding design of the diagnostic algorithm, making it clinical useful
11-16	Covers more than half the diseases and diagnostic criteria taught in the course.	The diagram/essay contains only minor errors. Does not substantially limit its use as a diagnostic tool.	Substantial further research. Application to diagnosis is systematic, effective, and thorough.	Evidence of advanced design incorporated in the diagnostic algorithm.
6-10	Covers less than half the diseases and diagnostic criteria, taught in the course.	The diagram/essay contains a few major errors. May limit its use as a diagnostic tool.	Clear evidence of research on diseases and diagnostic criteria, beyond the basic content	Design employs appropriate diagnostic principles, with at most minor errors.
0-5	Poor coverage of diseases and diagnostic criteria.	The diagram/essay contains major errors. Clearly incorrect diagnoses.	No additional content, beyond what was taught in the course, was correctly incorporated.	The rationale for the design is unremarkable or incorrect
Score
Total (out of 80): Mark (%):

SLMS Grade Descriptors the Kinetics and Metabolism coursework

Class	%	Criteria
Exceptional High 1^st Mid 1^st Low 1^st	90-100	Outstanding work suitable as a worked example in a student biochemistry text book.
81-90	Excellent work, showing a broad understanding of metabolic networks, kinetics and the biology of the enzyme that exceeds expectations for a first-year student. All aspects of the clue are well described in exceptional detail and depth. Expert processing and interpretation of the data. The student shows advanced understanding of the enzyme mechanism and how the inhibitor could be interacting with it.
76-80	A clear 1^st class answer. Includes all the relevant information relating to the topic. Very well-argued assay with high level of detail on all aspects of the metabolic clue. Correct processing, interpretation and reporting of the data. Conclusions demonstrate some insight into the mechanistic relationship of the enzyme and inhibitor. The submission as a whole demonstrates a higher level of understanding of enzyme kinetics as well as metabolic networks and their phenotypic consequences both at the cellular and organism level.
70-75	A high-quality quality submission with no errors or omissions and at least some evidence pointing to independent research.
High 2i Mid 2i Low 2i	66-69	A high-quality submission that is almost 1^st class but lack sufficient evidence of independent research.
65	A good submission, containing most of the required information, but also has minor errors/omissions and insufficient independent research
60-64	A good submission, containing most of the required information, but also has some non-trivial errors/omissions. Insufficient independent research
High 2ii Mid 2ii Low 2ii	56-59	The submission contains a substantial part of the required information, but there are several errors or omissions, or the rationale/explanation provided for the metabolic clue and experimental design were insufficient.
55	The submission contains a substantial part of the required information, but there are several errors or omissions, and the rationale/explanation provided for the metabolic clue and experimental design were insufficient.
50-54	The submission contains a substantial part of the required information, but there are several errors or omissions, the level of detail is insufficient throughout and the rationale provided on the clue/design is poor.
High 3^rd Mid 3^rd Low 3^rd	46-49	The submission contains just enough of the required information to warrant a pass, but there are multiple errors or omissions, or the level of detail is too low, and the rationale provided on the clue/design is wrong.
45	The submission contains just enough of the required information to warrant a pass, but there are multiple errors or omissions, and the level of detail is too low. The rationale provided on the clue/design is wrong.
40-44	The submission contains just enough of the required information to warrant a pass, but there are critical errors or omissions and the level of detail is low. The essay demonstrates poor understanding of the metabolic networks and the concepts of enzyme kinetics.
BorderlineFail Fail Clear Fail Weak Fail	35-39	An effort has been made but unfortunately the level of detail, and the content of the submission is insufficient to warrant a pass
25-34	An attempt has been made but the submission contain too many critical errors and omissions.
15-24	The submitted coursework does not match the criteria provided
1-14	Too little of the required coursework was submitted or the submission is incomprehensible and impossible to follow.
Zero	0	Submission contains nothing relevant to the objective or was not submitted

SLMS Grade Descriptors the Differential Diagnosis coursework

Class	%	Criteria
Exceptional High 1^st Mid 1^st Low 1^st	90-100	Outstanding work suitable for a current medical text book.
81-90	Excellent work, showing a broad understanding of the relevant disease areas, well beyond what is expected for a first-year student. The flow chart includes at least 1 disease beyond those in the storylines and the level on diagnostic criteria used is exceptional. The flow chart is well presented, and the essay is clear concise and very well argued
76-80	A clear 1^st class answer. Includes all the relevant information relating to the topic. Very well-argued assay and a high-quality diagram with either exceptional detail on the diagnostic criteria or at least one additional disease. Demonstrates a higher level of understanding of the disease areas.
70-75	A high-quality flow chart and essay with no errors or omissions and at least one piece of evidence pointing to independent research.
High 2i Mid 2i Low 2i	66-69	A high-quality flow chart and essay that are almost 1^st class but lack evidence of independent research.
65	A good flow chart and well-argued essay, containing most of the required information, but also has minor errors/omissions.
60-64	A good flow chart and well-argued essay, containing most of the required information, but also has some errors/omissions.
High 2ii Mid 2ii Low 2ii	56-59	The flow chart contains a substantial part of the required information, but there are several errors or omissions, or the detail and arguments made in the essay were insufficient.
55	The flow chart contains a substantial part of the required information, but there are several errors or omissions and the detail and arguments made in the essay were insufficient.
50-54	The flow chart contains a substantial part of the required information, but there are several errors or omissions, the level of detail is insufficient throughout and the rationale in the essay is poorly explained.
High 3^rd Mid 3^rd Low 3^rd	46-49	The flow chart contains just enough of the required information to warrant a pass, but there are multiple errors or omissions, or the level of detail is too low and the explanation provided in the essay is wrong or inappropriate.
45	The flow chart contains just enough of the required information to warrant a pass, but there are multiple errors or omissions and the level of detail is low. The essay is poorly argued, wrong or inappropriate.
40-44	The flow chart contains just enough of the required information to warrant a pass, but there are critical errors or omissions and the level of detail is low. The essay demonstrates poor understanding of the disease process.
BorderlineFail Fail Clear Fail Weak Fail	35-39	An effort has been made but unfortunately the level of detail, and the content of the flow chart is insufficient to warrant a pass
25-34	An attempt has been made but the flow chart and essay contain several critical errors and omissions.
15-24	The submitted coursework does not match the criteria provided
1-14	Too little of the required coursework was submitted or the submission is incomprehensible and impossible to follow.
Zero	0	Submission contains nothing relevant to the objective or was not submitted