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Paracetamol (acetaminophen) is a widely available over-the-counter analgesic antipyretic. ?It has a long history of use in the general public, however, it has a number of classical toxicities associated with it. It is loosely classified as a non-steroidal anti-inflammatory drug (NSAID).
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You have been asked by management to compare a potential topical preparation of Paracetamol (acetaminophen) with one containing diclofenac. The objectives are to
?Compare potential toxicities particularly considering topical administration
oBoth are known oral products; how might topical administration affect toxicity?
?To indicate if any new testing of the proposed paracetamol product might be needed – or to say why it is not needed
?Are there any potential non-clinical or clinical issues or problems that may be associated with this project?
?To make a recommendation as to whether to develop a topical formulation of paracetamol.
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This should follow this contents list; comment may be brief but you need to show that you have considered each point.
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1.?????????INTRODUCTION
2.?????????METHODS
3.?????????PHARMACOLOGY – brief comparative summary
4.?????????PHARMACOKINETICS
5.?????????TOXICOLOGY
5.1 Single-dose toxicity
5.2 Repeat-dose toxicity
5.3 Genotoxicity
5.4 Carcinogenicity
5.5 Reproductive and Developmental toxicity
5.6 Local Tolerance / Other toxicity studies?(what do you expect here?)
6.?????????CLINICAL EXPERIENCE?(just a summary, including clinical dosage)
7.?????????DISCUSSION & RECOMMENDATION
8.?????????REFERENCES
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In total, your report should be no more than 2000 words excluding references, figure legends and titles.?
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Your report should be formatted according to the following requirements:
Ariel,?
size 12,
Double line spacing
Harvard referencing style